Life science stories you may have missed – October, 2021

Life science stories you may have missed – October, 2021

Meet the Scientists Behind mRNA Vaccines

Drs. Katalin Karikó and Drew Weissman met photocopying journal articles and soon began working together to better understand mRNA. Together, they discovered a breakthrough: how to make mRNA non-inflammatory to enable development of cutting-edge mRNA-based vaccines. In a video from Penn Medicine, they explain how the technology is now being used to develop everything from a gene therapy for sickle cell anemia to vaccines for peanut allergies.

Watch the Penn Medicine video.

A New Approach to Understanding Cancer: Protein Mapping

After more than a decade of research, scientists from the Cancer Cell Map Initiative have published a series of papers outlining a new approach to map protein networks underlying different types of cancer. The technique holds promise to help understand what is driving cancer and identify new therapeutic targets. “Looking at cancer at the protein level could help organize the mess of genetic data into a simpler understanding of the pathways that are driving disease,” Andrew Joseph writes in a recent article for STAT.

Read the full article in STAT.

Antiviral Pills for COVID-19 Now in Clinical Trials

“Oral antivirals have the potential to not only curtail the duration of one’s COVID-19 syndromes, but also have the potential to limit transmission to people in your household if you’re sick,” Timothy Sheahan, a virologist at the University of North Carolina-Chapel Hill, told NBC News. Unlike remdesivir, the only antiviral currently approved to treat COVID, the drugs now in clinical trials can be packaged as pills.

Read the full NBC News article.

Healthcare provider stories you may have missed – September 20201

Healthcare provider stories you may have missed – September 20201

The FDA formally authorized booster shots of the Pfizer-BioNTech vaccine for adults over 65, those who are at high risk of severe Covid-19, or those who are at risk of serious complications because of exposure to the virus in their jobs. There’s a lot of ambiguity in those requirements. Now the question turns to who exactly needs a booster shot and when? The New York Times writes: “Roughly 22 million Americans are at least six months past their second Pfizer dose, according to the C.D.C. About half are 65 or older. But who exactly risks becoming severely ill? What does it mean to be exposed on the job? Do teachers count as exposed, or just frontline health care workers? And what about Americans who got the Moderna and Johnson & Johnson shots?”

One day after the FDA announcement, scientists on the C.D.C.’s Advisory Committee on Immunization Practices began tackling these complicated issues. Director Rochelle Walensky signed off on a series of recommendations, saying boosters should be offered to people 65 and over as well as those 50 to 64 years with underlying medical conditions. People with underlying medical conditions ages 18-49 may also get shots. The extra dose would be given at least six months after the last shot. But one of Dr. Walensky’s endorsements broke from the panel’s recommendation, saying people may be offered boosters if they are ages 18 to 64 years and are healthcare workers or have another job that puts them at increased risk of being exposed to the virus.

And just as the booster shot campaign begins, hospitals across the country are grappling with workforce burnout and staffing shortages. Lisa Tomasso, spokeswoman for the Hospital Association of Rhode Island, told the Boston Globe, “The healthcare workforce shortage existed prior to COVID-19. The pandemic and its protracted nature have only exacerbated that problem.” In New York, hospitals and nursing homes are bracing for the possibility that a statewide COVID-19 vaccine mandate for health care workers could lead to staff shortages when it takes effect Monday. To ensure there’s enough staff to care for all the patients, hospitals and nursing homes were preparing contingency plans that included cutting back on elective surgeries and, at one hospital, halting maternity services.

Finally, taking a novel and innovative approach to tackling health inequities, Blue Cross Blue Shield of Massachusetts will begin paying doctors more money if they close longstanding, harmful gaps in care for people of color. In an interview with WBUR, Dr. Mark Friedberg, Blue Cross Blue Shield of Massachusetts Senior Vice President of Performance Measurement and Improvement, said, “We are taking these steps to really, in an intentional way, try to improve the equity of care, because this has been a longstanding interest of the company.” Details of the financial incentives are still being worked out, but they would apply to doctors who care for Blue Cross Blue Shield members in Massachusetts and could be implemented by 2023.

Clients in the news – Week of September 13, 2021

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